POSTERS

DEEP BODY PEPTIDERGIC AFFERENTS LACK ADVILLIN EXPRESSION: IMPLICATIONS FOR SENSORY NEURON PROFILING
Niemczycka J.¹, Bernacka J.¹, Lopes D.M.², Bannister K.³, Kucharczyk M.^1,4
1 Łukasiewicz Research Network - PORT Polish Center for Technology Development, ul. Stabłowicka 147, 54-066, Wrocław, Poland, ² University College London, Department of Neuromuscular Diseases, Gower Street, London WC1E 6BT, UK, ³ Imperial College London, Department of Life Sciences, South Kensington, London SW7 2AZ, UK, ⁴ King’s College London, Wolfson Sensory, Pain and Regeneration Centre, London SE1 1UL, UK

PIEZO2-DEPENDENT RAPID PAIN SYSTEM IN HUMANS AND MICE
Brodzki M.¹, Bouchatta O.¹, Manouze H.¹, Carballo G.B.¹, Yu H.², Kindström E.¹, de- Faria F.M.¹, Thorell O.^1,3, Liljencrantz J.^4,5, Karlsson C.¹, Maidana Capitán M.B.¹, W. Ng K.K.¹, Terejko K.^1,6, Larsson M.¹, Luo W.², Marshall A.G.^1,7, Chesler A.T.^4,8, Olausson H.¹, Nagi S.S.^1,3, Szczot M.^1
1 Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden, ² Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA, ³ School of Medicine, Western Sydney University, Sydney, Australia, ⁴ National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, USA, ⁵ Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ⁶ Łukasiewicz Research Network - PORT Polish Center for Technology Development, Wroclaw, Poland, ⁷ Institute of Life Course and Medical Sciences, University of Liverpool, UK, ⁸ National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA

BEHAVIOURAL, ELECTROPHYSIOLOGICAL AND HISTOLOGICAL CHANGES IN A NEW MODEL OF ANOSMIA
Podolecka W., Hunt M.J.
Nencki Institute of Experimental Biology, PAS

CHANGES IN SYNAPTIC TRANSMISSION FROM MUSCLE SPINDLES TO MOTONEURONS IN RESPONSE TO ENDURANCE TRAINING
Krutki P.¹, Krauze M.¹, Drzymała-Celichowska H.², Bączyk M.^1
1 Poznan University of Physical Education, Department of Neurobiology, Poznan, Poland, ² Poznan University of Physical Education, Department of Biochemistry, Poznan, Poland

CHANGES IN SYNAPTIC TRANSMISSION FROM MUSCLE SPINDLES TO MOTONEURONS IN RESPONSE TO WEIGHT-LIFTING TRAINING
Krauze M.¹, Bączyk M.¹, Drzymała-Celichowska H.², Krutki P.^1
1 Poznan University of Physical Education, Department of Neurobiology, Poznan, Poland, ² Poznan University of Physical Education, Department of Biochemistry, Poznan, Poland

THE IMPACT OF ANODAL AND CATHODAL TSDCS ON PASSIVE MEMBRANE AND FIRING PROPERTIES OF SPINAL MOTONEURONS IN SOD1 G93A MICE
Bączyk M., Wasicki B., Zawistowski P.
Poznań University of Physical Education, Department of Neurobiology, Poznań, Poland

THE EFFECTS OF ELECTRODE CONFIGURATION ON MNS' RESPONSE TO TSDCS.
Wasicki B., Zawistowski P., Bączyk M.
Poznan University of Physical Education, Neurobiology Department, Królowej Jadwigi 27/39, 61-871 Poznań, Poland

CONCOMITANT EFFECTS OF FATIGUE AND POTENTIATION IN RAT MEDIAL GASTROCNEMIUS FAST MOTOR UNITS
Angelidis A.¹, Drzymała-Celichowska H.^2,3, Kryściak K.², Vandenboom R.¹, Celichowski J.^2
1 Department of Kinesiology, Centre for Bone and Muscle Health, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, ON, L2S 3A1, Canada, ² Department of Neurobiology, Poznan University of Physical Education, 27/39 Królowej Jadwigi, 61-871 Poznan, Poland, ³ Department of Physiology and Biochemistry, Poznan University of Physical Education, 27/39 Królowej Jadwigi, 61-871 Poznan, Poland

THE ROLE OF CAP2 IN THE NEUROMUSCULAR SYSTEM
Wójcicka O.¹, Cicco T.D.¹, Kepser L.², Field J.³, Rust M.², Prószyński T.J.^1
1 Synaptogenesis Research Group, Łukasiewicz Research Network PORT – Polish Centre of Technology Development, Stablowicka 147, 54-066, Wrocław, Poland, ² Molecular Neurobiology Group, Institute of Physiological Chemistry, University of Marburg, 35032 Marburg, Germany, ³ Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

SH3BP2- A NEW REGULATOR OF NEUROMUSCULAR SYNAPSES
Pradhan B.S.^1,2, Bernadzki K.², Bandaruk Y.¹, Siudzińska A.¹, Cicco T.D.¹, Sotomska M.¹, Gawor M.², Krzemień J.², Chodaczek G.¹, Hashemolhosseini S.^3,1, Prószyński T.J.^1,2
1 Łukasiewicz Research Network — PORT Polish Center for Technology Development, 147 Stabłowicka Street, 54-066 Wrocław, Poland., ² Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02- 093 Warsaw, Poland, ³ Institute of Biochemistry, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany

THE ROLE OF DOPAMINE-SENSITIVE MOTOR CORTICAL CIRCUITS IN THE DEVELOPMENT AND EXECUTION OF SKILLED FORELIMB MOVEMENTS
Gorkowska-Nosal M.^1,2, Drwięga G.¹, Szumiec Ł.³, Parkita J.R.³, Cieślak P.E.^1
1 Jagiellonian University, Institute of Zoology and Biomedical Research, Department of Neurophysiology and Chronobiology, 9 Gronostajowa St., Krakow, Poland, ² Jagiellonian University, Doctoral School of Exact and Natural Sciences, 11 Łojasiewicza St., Krakow, Poland, ³ Maj Institute of Pharmacology Polish Academy of Sciences, Department of Molecular Neuropharmacology, 12 Smętna St., Krakow, Poland

EFFECTS OF LATERALIZED VISUAL STIMULATION ON MIDBRAIN DOPAMINERGIC NEURON ACTIVITY AND STRIATAL DOPAMINE RELEASE DYNAMICS
Marzec M.^1,2, Nowalińska K.¹, Błasiak T.^1
1 Jagiellonian University, Institute of Zoology and Biomedical Research, Department of Neurophysiology and Chronobiology, 9 Gronostajowa St., Cracow, Poland, ² Jagiellonian University, Doctoral School of Exact and Natural Sciences, 11 Łojasiewicza St., Cracow, Poland

TIME NECESSARY TO RESTITUTE EXTRA INITIAL FORCE IN FAST MOTOR UNITS IN RAT MEDIAL GASTROCNEMIUS MUSCLE
Kryściak K.¹, Drzymała-Celichowska H.^1,2, Majerczak J.³, Celichowski J.¹, Zoladz J.A.^3
1 Poznan University of Physical Education, Department of Neurobiology, Królowej Jadwigi 27/39, 61-871 Poznań, Poland., ² Poznan University of Physical Education, Department of Physiology and Biochemistry, Królowej Jadwigi 27/39, 61-871 Poznań, Poland., ³ Jagiellonian University Medical College, Faculty of Health Sciences, Chair of Exercise Physiology and Muscle Bioenergetics, Skawińska 8, 31-066 Kraków, Poland.

TREADMILL TRAINING VERSUS VOLUNTARY WHEEL RUNNING: EFFECTS IN CONTRACTILE PROPERTIES OF THE THREE TYPES OF MOTOR UNITS IN RAT MEDIAL GASTROCNEMIUS MUSCLE
Podgórski K.¹, Kryściak K.¹, Drzymała-Celichowska H.¹, Śliwowska J.², Celichowski J.^1
1 Poznan University of Physical Education, Department of Neurobiology, 27/39 Królowej Jadwigi St., Poznan, Poland, ² University of Life Sciences in Poznan, Department of Zoology, 71C Wojska Polskiego St., Poznan, Poland

POST-STROKE SOMATOSENSORY DEFICITS ARE REFLECTED IN ALTERED ACTIVITY OF SPINAL WDR NEURONS
Bernacka J.¹, Jurczyk J.³, Krzyżanowska W.⁴, Pomierny B.³, Kucharczyk M.^1,2
1 Cancer Neurophysiology Group, Łukasiewicz Research Network - PORT Polish Center for Technology Development, ul. Stabłowicka 147, 54-066, Wroclaw, Poland, ² Wolfson Sensory, Pain and Regeneration Centre, King’s College London, SE1 1UL London, UK, ³ Imaging Laboratory, Center for the Development of Therapies for Civilization and Age-Related Diseases, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland, ⁴ Jagiellonian University Medical College, Department of Toxicological Biochemistry, Chair of Toxicology, Medyczna 9, 30-688 Kraków, Poland

PROTEOMIC ALTERATIONS AFTER SPINALIZATION: PERSPECTIVES FROM MOTONEURONS, DORSAL ROOT GANGLIA, AND EPENDYMA
Gajewska-Woźniak O.^1,2, Głowacka A.², Pytyś A.¹, Wójtowicz T.¹, Radwanska K.¹, Skup M.^2
1 Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology, ² Group of Restorative Neurobiology, Nencki Institute of Experimental Biology

IDENTIFICATION OF A NOVEL GENETIC MOUSE MODEL OF BIPOLAR DISORDER REVEALING SEX DIFFERENCES
Kischel A.¹, Krzemień J.², Sadlak-Buda J.¹, Duda P.¹, Garmash I.¹, Joshi I.¹, Rojek K.², Kaczor P.¹, Jakubas M.¹, Myrcha M.¹, Boguszewski P.², Holmgren L.³, Prószyński T.J.^1
1 Łukasiewicz Research Network — PORT Polish Center for Technology Development, 147 Stabłowicka Street, 54-066 Wrocław, Poland., ² Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland., ³ Karolinska institutet, Department of Oncology-Pathology, Bioclinicum, Stockholm 17164, Sweden.

MITOCHONDRIAL CALCIUM UNIPORTER PROTECTS HIPPOCAMPAL CA2 NEURONS FROM EXCITOTOXIC INJURY
Skweres A., Beręsewicz-Haller M., Basheer O., Nalepa M., Owczarek A., Kawalec M., Gruszczynska-Biegala J., Zabłocka B., Węgrzynowicz M.
¹ Mossakowski Medical Research Institute, Polish Academy of Sciences, Laboratory of Molecular Basis of Neurodegeneration, Pawińskiego 5, 02-106, Warsaw, Poland, ² Centre of Postgraduate Medical Education, Doctoral School of Translational Medicine, Marymoncka 99/103, 01-813 Warsaw, Poland, ³ Mossakowski Medical Research Institute, Polish Academy of Sciences, Molecular Biology Unit, Pawińskiego 5, 02-106, Warsaw, Poland

LOST ENZYME, LOST INTEGRITY: ARGINASE 2 DELETION DISRUPTS MITOCHONDRIA IN STRIATAL NEURONS
Nalepa M.¹, Szymanowski J.², Skweres A.¹, Czarnecka K.¹, Owczarek A.¹, Gewartowska M.³, Szczepanowska K.⁴, Węgrzynowicz M.^1
1 Mossakowski Medical Research Institute, Polish Academy of Sciences, Laboratory of Molecular Basis of Neurodegeneration, 5 Pawinskiego St.,Warsaw, Poland, ² Mossakowski Medical Research Institute, Polish Academy of Sciences, Laboratory of Advanced Microscopy Techniques, 5 Pawinskiego St., Warsaw, Poland, ³ Mossakowski Medical Research Institute, Polish Academy of Sciences, Electron Microscopy Research Unit, 5 Pawinskiego St., Warsaw, Poland, ⁴ International Institute of Molecular Mechanisms and Machines, Polish Academy of Sciences, Laboratory of Metabolic Quality Control, 6 Flisa St., Warsaw, Poland

SEX-SPECIFIC ALTERATIONS IN MITOCHONDRIAL DYNAMICS AND AMPK SIGNALLING IN A TRAP1 MUTANT MICE- A NOVEL MODEL OF ASD.
Malicka D., Stawikowska A., Dziembowska M., Kuźniewska B.
Laboratory of Molecular Neurobiology, Faculty of Biology, University of Warsaw, Warsaw, Poland

ALTERED MITOCHONDRIAL METABOLISM IN THE BRAINS OF TRAP1 MUTANT MICE, A MODEL FOR AUTISM SPECTRUM DISORDER (ASD)
Kuźniewska B., Malicka D., Dziembowska M.
Laboratory of Molecular Neurobiology, Faculty of Biology, University of Warsaw, Warsaw, Poland

ELECTROPHYSIOLOGICAL AND ANATOMICAL CHARACTERISTICS OF VENTRAL DENTATE GYRUS INTERNEURONS IN A RAT MODEL OF AUTISM SPECTRUM DISORDER
Nogaj A., Kula K., Blasiak A.
Department of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland

CHANGES IN BRAIN BIOELECTRICAL ACTIVITY FOLLOWING TRANSCRANIAL DIRECT CURRENT STIMULATION IN INDIVIDUALS WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD) AND AUTISM SPECTRUM DISORDER (ASD).
Skuła M.^1,2, Budzisz J.³, Fila-Pawłowska K.⁴, Ślęzak M.², Kajdanowicz T.¹, Rymaszewska J.^4
1 Wroclaw University of Science and Technology - Faculty of Information and Communication Technology, Department of Artificial Intelligence, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland, ² Łukasiewicz Research Network PORT – Polish Centre of Technology Development, Biology of Astrocytes Group, Stabłowicka 147, 54-066, Wrocław, Poland, ³ Wroclaw University of Science and Technology - Faculty of Electrical Engineering, Department of Electrical Power Engineering, ul. Janiszewskiego 8, 50-372, Wrocław, Poland, ⁴ Wroclaw University of Science and Technology, Faculty of Medicine - Department of Clinical Neuroscience, Hoene-Wrońskiego 13c, 50-372, Wrocław, Poland

SPNAR9810Q MICE: DEEP BEHAVIORAL AND MOLECULAR PHENOTYPING OF SPONTANEOUS SPECTRINOPATHY MODEL
Ziuzia P.^1,2, Hoinkis D.³, Opałek M.⁴, Ślęzak M.¹, Miążek A.^2
1 Łukasiewicz Research Network - PORT Polish Center for Technology Development, Life Sciences and Biotechnology Center, Stabłowicka 147, Wrocław, Poland, ² Wroclaw University of Environmental and Life Sciences, Department of Biochemistry and Molecular Biology, Norwida 25, Wrocław, Poland, ³ Maj Institute of Pharmacology Polish Academy of Sciences, Department of Molecular Neuropharmacology, Smętna 12, Kraków, Poland, ⁴ Intelliseq Inc., Wilczyńskiego 19, Kraków, Poland

MOLECULAR CHALLENGES IN HEREDITARY SPINOCEREBELLAR DEGENERATIONS
Méreaux J., Coarelli G., Davoine C., Guillot-Noel L., Heinzmann A., Ewenczyk C., Brice A., Durr A.
Sorbonne Université, Institut du Cerveau - Paris Brain Institute- ICM, Inserm, CNRS, APHP, University Hospital Pitié-Salpêtrière, Paris, France

INTER-STRAIN CHIMERAS REVEAL NEURODEVELOPMENTAL MECHANISMS OF CORPUS CALLOSUM AGENESIS IN A MOUSE MODEL
Sampino S.¹, Ziętek M.¹, Winiarczyk D.¹, Viscomi M.P.¹, Żbikowska D.¹, Czyrska J.¹, Cybulska M.¹, Wenta-Muchalska E.¹, Bernat A.^2
1 Department of Experimental Embryology, Institute of Genetics and Animal Biotechnology PAS, ul Postępu 36A, Jastrzębiec, Poland, ² Laboratory of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk & Medical University of Gdansk, Gdansk, Poland

BEYOND CEREBRUM AND NEUROSURGERY: A SYSTEMATIC REVIEW ON CHIARI MALFORMATION TYPE I INTEGRATING MOLECULAR AND BEHAVIORAL METHODOLOGIES
Oezdil I.^1,2, Aprile D.³, Beste C.^1,4,5
1 Faculty of Psychology, School of Science, TU Dresden, Dresden, Germany, ² Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, TU Dresden, Dresden, Germany, ³ Human Technopole, Viale Rita Levi Montalcini 1, 20157 Milan, Italy, ⁴ Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany, ⁵ University Neuropsychology Center, Faculty of Medicine, TU Dresden, Dresden, Germany

TARGETING NEUROINFLAMMATION IN THE BRAIN: EFFECTS OF THE PUTATIVE CANNABINOID RECEPTOR GPR55 LIGANDS CBD, O-1602, AND ML-193 IN MIXED GLIAL CELL CULTURES
Degutis M., Popiołek-Barczyk K., Starowicz K.
Maj Institute of Pharmacology Polish Academy of Sciences, Department of Neurochemistry, Smętna 12, Kraków, Poland

Β-HYDROXYBUTYRATE ALTERS NEUROINFLAMMATORY RESPONSE AND CELL MIGRATION ABILITIES AFTER THE SCRATCH INJURY IN VITRO
Rauk Z.^1,2, Maciak P.^1,3, Tylko G.⁴, Romek M.⁴, Setkowicz Z.², Duda M.^3
1 Jagiellonian University, Doctoral School of Exact and Natural Sciences, Łojasiewicza 11, 30-348 Kraków, Poland, ² Jagiellonian University, Faculty of Biology, Laboratory of Experimental Neuropathology, Gronostajowa 9 Street, 30-387 Krakow, Poland, ³ Jagiellonian University, Faculty of Biology, Department of Endocrinology, Gronostajowa 9 Street, 30-387 Krakow, Poland, ⁴ Jagiellonian University, Faculty of Biology, Department of Cell Biology and Imaging, Gronostajowa 9, 30-387 Krakow, Poland

OXIDATIVE STRESS IN PRIMARY MICROGLIAL CELLS DUE TO EXPOSURE TO PLASTIC NANOPARTICLES
Adamiak K.^1,2, Strużyńska L.^1
1 Mossakowski Medical Research Institute Polish Academy of Sciences (5 Adolfa Pawińskiego Street, 02-106 Warsaw, Poland), ² Doctoral School of Translational Medicine, Centre of Postgraduate Medical Education (99/103 Marymoncka Street, 01-813 Warsaw, Poland)

THERAPEUTIC POTENTIAL OF PAPE-1 AGAINST HYPOXIC/ISCHEMIC BRAIN INJURY: A DUAL NEURON - GLIA TARGETED APPROACH
Łach A.¹, Przepiórska-Drońska K.², Pietrzak-Wawrzyńska B.A.², Płonka W.¹, Wnuk A.^1
1 Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Drug Addiction Pharmacology, Team I, Smetna Street 12, 31–343 Krakow, Poland; lach@if-pan.krakow.pl, wnuk@if-pan.krakow.pl, ² Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Drug Addiction Pharmacology, Laboratory of Neuropharmacology and Epigenetics, Smetna Street 12, 31–343 Krakow, Poland

SORCS2 SHIELDS ASTROCYTES FROM AMYLOID BETA (AΒ) STRESS BY REGULATING P75 NTR SIGNALING
Ziemlińska E.¹, Schmidt V.², Wilnow T.E.², Malik A.R.^1
1 University of Warsaw, Faculty of Biology, Warsaw, Poland, ² Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

SORCS2 SHAPES THE SECRETOME OF ASTROCYTES ACTIVATED AFTER ISCHEMIC STROKE.
Tempes A.¹, Bakun M.², Czerny K.¹, Piątek S.^1,3, Koschützke L.T.³, Daugardt A.³, Jariwala V.⁴, Joseph K.⁴, Harms C.³, Malik A.R.^1
1 University of Warsaw, Faculty of Biology, Cellular Neurobiology Research Group, Miecznikowa 1, Warsaw, Poland, ² Polish Academy of Sciences, Institute of Biochemistry and Biophysics, Warsaw, Poland, ³ Charité-Universitätsmedizin Berlin, Department of Experimental Neurology, Berlin, Germany, ⁴ Medical Center- University of Freiburg, Department of Neurosurgery, Laboratory for NeuroEngineering, Freiburg, Germany

ALTERATIONS OF IMMUNE CHECKPOINT PROTEINS IN ANIMAL MODELS OF DEPRESSION-LIKE BEHAVIOR
Curzytek K.¹, Kamińska K.¹, Wiekiera A.², Malicki S.³, Głombik K.¹, Basta-Kaim A.¹, Kubera M.^1
1 Maj Institute of Pharmacology Polish Academy of Sciences,Department of Experimental Neuroendocrinology, Smętna street 12, 31-343 Kraków, Poland, ² Jagiellonian University, Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Gronostajowa 7 street, 30-387 Kraków, Poland, ³ Jagiellonian University, Malopolska Centre of Biotechnology, Gronostajowa 7 street, 30-387 Kraków, Poland

INFLUENCE OF PSYCHOSOCIAL OVERCROWDING STRESS ON THE EXPRESSION OF INFLAMMATORY FACTORS IN THE RAT COLON
Heliasz M., Roman A., Bielawski A., Kreiner G., Zelek-Molik A.
Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Brain Biochemistry, Smętna 12, 31-343, Kraków, Poland

MODULATION OF NMDA RECEPTOR SUBUNIT EXPRESSION BY (R,S)-SULFORAPHANE IN THE OLFACTORY BULBECTOMY MODEL IN MICE
Jakubowska B.¹, Sowa-Kućma M.^2,,3, Sołek P.^4,,5, Pańczyszyn-Trzewik P.^2
1 Students Science Club "NEURON", Faculty of Medicine, Collegium Medicum, University of Rzeszów, Rzeszow, Poland, ² Department of Human Physiology, Faculty of Medicine, Collegium Medicum, University of Rzeszów, Rzeszow, Poland, ³ Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, Collegium Medicum, University of Rzeszów, Rzeszow, Poland, ⁴ Department of Biochemistry and Toxicology, University of Life Sciences, Lublin, Poland, ⁵ Department of Biopharmacy, Medical University of Lublin, Lublin, Poland

EFFECTS OF CHRONIC MILD STRESS AND ESCITALOPRAM ON GLUCAGON-LIKE PEPTIDE-1 AND FUNCTIONALLY RELATED PROTEINS IN THE FRONTAL CORTEX OF RATS.
Dyndał K.¹, Sowa-Kućma M.^2,3, Gałka N.², Papp M.⁴, Pańczyszyn-Trzewik P.^2
1 Students Science Club "NEURON", Faculty of Medicine, Collegium Medicum, University of Rzeszów, Rzeszow, Poland, ² Department of Human Physiology, Faculty of Medicine, Collegium Medicum, University of Rzeszów, Rzeszow, Poland, ³ Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, Collegium Medicum, University of Rzeszów, Rzeszow, Poland, ⁴ Department of Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland

DISTINCT MICRORNA SIGNATURES OF CHILDHOOD TRAUMA IN HUMAN SERUM AND SPERM: IMPLICATIONS FOR POTENTIAL INTERGENERATIONAL TRANSMISSION
Nadalinska R.¹, Gomółka M.^1,2, Tomaszewska W.^1,2, Gbadamosi I.^1,2, Hidayat T.¹, Jawaid A.^1
1 Translational Neuropsychiatry Research Group (TREND Lab), Łukasiewicz Research Network - PORT Polish Center for Technology Development, Wroclaw, Poland, ² Laboratory for Translational Research in Neuropsychiatric Disorders (TREND Lab), Nencki Institute of Experimental Biology, Warsaw, Poland

FROM DIET TO DEMENTIA: THE WESTERN DIET'S INFLUENCE ON ALZHEIMER'S VIA THE LIVER-BRAIN AXIS AND SYSTEMIC MARKERS.
Mietelska-Porowska A., Domańska J., Więckowska-Gacek A., Wojda U.
Nencki Institute of Experimental Biology, Polish Academy of Sciences in Warsaw, Laboratory of Preclinical Testing of Higher Standard, 3 Pasteur St., Warsaw, Poland

BRAIN ENERGY IMBALANCE AND INFLAMMATORY RESPONSE IN BBB DYSFUNCTION IN APOE-/-/LDLR-/- MICE DURING HYPERCHOLESTEROLEMIA
Czuba-Pakuła E.¹, Pelikant-Małecka I.², Głowiński S.³, Lietzau G.¹, Smoleński R.T.⁴, Kowiański P.^1,3
1 Medical University of Gdańsk, Department of Anatomy and Neurobiology, 1 Dębinki Str., 80-211 Gdańsk, Poland, ² Medical University of Gdańsk, Division of Medical Laboratory Diagnostics ‑ Fahrenheit Biobank BBMRI.pl, 1 Dębinki Str., 80-211 Gdańsk, Poland, ³ Pomeranian University of Słupsk, Department of Health Sciences, 64 Bohaterów Westerplatte Str., 76-200 Słupsk, Poland, ⁴ Medical University of Gdańsk, Department of Biochemistry, 1 Dębinki Str., 80-211 Gdańsk, Poland

COMPENSATORY NEUROGENESIS AND NEUROPEPTIDE NETWORK IN THE PREVENTION OF HYPERPHAGIA IN A DICER-DEFICIENT MOUSE MODEL OF HYPOTHALAMIC OBESITY
Vodianytskyi M.U.¹, Pietrzyk O.¹, Konopka A.², Konopka W.^1
1 Łukasiewicz Research Network - PORT Polish Center for Technology Development, Life Sci, Neuroplasticity and Metabolism Group, Stabłowicka 147, 54-066 Wrocław, Poland, ² Łukasiewicz Research Network - PORT Polish Center for Technology Development, Life Sciences and Biotechnology Core Facility Laboratory

THE EFFECT OF RETINAL DOPAMINE SIGNALING ON THE BEHAVIORAL RHYTHMS
Zaborski M., Damulewicz M.
Jagiellonian University, Institute of Zoology and Biomedical Research, Department of Cell Biology and Imaging, Gronostajowa 9, 80-387 Kraków, Poland

MITOPHAGY DISRUPTION LEADS TO THE CIRCADIAN RHYTHMICITY DISORDER IN DROSOPHILA MELANOGASTER
Zientara K., Damulewicz M.
Institute of Zoology and Biomedical Research, Department of Cell Biology and Imaging, Jagiellonian University, Gronostajowa 9 St., Kraków, Poland

HALLUCINATIONS AS A CONSEQUENCE OF PREDICTIVE CODING AND BAYESIAN INFERENCE DISRUPTIONS: A SYSTEMATIC REVIEW ACROSS PSYCHOSIS, PSYCHEDELICS, AND SENSORY DEPRIVATION WITH MACHINE LEARNING PERSPECTIVES
Aakanksha A.¹, Chatterjee I.^2
1 Tbilisi State Medical University, Department of Neurology, 33 Vazha Pshavela Avenue, Tbilisi 0159, Georgia, ² Manchester Metropolitan University, Department of Computing and Mathematics, Manchester M1 5GD, United Kingdom.

KETAMINE INDUCED REORGANIZATION OF BRAIN ACTIVITY: SPIKE ACTIVITY AND CHANGES IN GAMMA AND HIGH-FREQUENCY OSCILLATIONS
Bramorska A., Hunt M.J.
Nencki Institute of Experimental Biology of Polish Academy of Sciences, Laboratory of Neuroinformatics, 3 Pasteur St., Warsaw, Poland

CALMODULIN CONTROLS SPATIAL AND TEMPORAL SPECIFICITY OF CALCIUM TRANSIENTS
Jędrzejewska-Szmek J.
Nencki Institute of Experimental Biology PAS, ul. Pasteura 3, 02-093 Warszawa, Poland

CHARACTERIZATION OF THE CEREBRAL CORTEX IN THE NON-HUMAN PRIMATE BRAIN: A DEEP LEARNING MODEL INTERPRETABILITY APPROACH
Datta A.¹, Kulesza A.¹, Syc M.¹, P. Rosa M.G.², Majka P.^1,2
1 Institute of Experimental Biology, Laboratory of Neuroinformatics, 3 Pasteur St., Warsaw, Poland, ² Biomedicine Discovery Institute, Monash University, Department of Physiology and Neuroscience Program, Wellington Rd, Clayton VIC 3800, Australia

OMENTIN-1 IS REGULATED BY KISSPEPTIN AND ESTRADIOL AND MODULATES GNRH SIGNALING VIA PKC, ERK1/2, AND CAMP PATHWAYS IN MOUSE GT1-7 NEURONS
Respekta-Długosz N.^1,2, Wachowska D.^1,2, Froment P.³, Dupont J.³, Rak A.^1
1 Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, Krakow, Poland, ² Doctoral School of Exact and Natural Sciences, Jagiellonian University, Łojasiewicza 11, Krakow, Poland, ³ INRAE, Physiologie de la Reproduction et des Comportments, Nouzilly, France

THE EFFECTS OF SLEEP DEPRIVATION ON GUT CONDITION – DROSOPHILA MELANOGASTER MODEL.
Siwarga M., Damulewicz M.
Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Cracow, Poland

A ROLE OF ASTROCYTIC IGFBP2 IN DENDRITIC SPINE STRUCTURAL PLASTICITY
Rutkowska M., Legutko D., Bijoch Ł., Kaczmarek L., Michaluk P.
Nencki Institute of Experimental Biology PAS, Department of Neurobiology, Ludwika Pasteura 3, 02-093 Warsaw, Poland

ASTROCYTE-DERIVED SYNAPTIC PROTEINS MEDIATE STRESS-INDUCED BEHAVIORAL CHANGES AND MODULATE ANTIDEPRESSANT RESPONSES IN MICE.
Lech A.M.¹, Zglinicki B.¹, Ziuzia P.^1,2, Skuła M.^1,3, Ślęzak M.^1
1 Lukasiewicz Research Network – PORT Polish Center for Technology Development, Stablowicka 147 St., Wroclaw, Poland, ² Wroclaw University of Environmental and Life Sciences, Norwida 25 St., Wroclaw, Poland, ³ Wroclaw University of Science and Technology, 27 Wybrzeże Stanisława Wyspiańskiego St., Wroclaw, Poland

FOCAL ADHESION KINASE MODULATION COUNTERACTS DENDRITIC SPINE REMODELING INDUCED BY CORTICOSTERONE IN CORTICAL AND HIPPOCAMPAL NEURONS
Wilczkowski M., Zelek-Molik A., Kączek K., Nalepa I.
Polish Academy of Sciences, Maj Institute of Pharmacology, Department of Brain Biochemistry, Kraków, Poland

REGULATED EXOCYTOSIS IN ASTROCYTES
Mielnicka A., Kaczmarek L., Michaluk P.
Nencki Institute of Experimental Biology PAS, Department of Neurobiology, Ludwika Pasteura 3, 02-093 Warsaw, Poland

GLUCOCORTICOID RECEPTOR SIGNALING ORCHESTRATES CIRCADIAN RHYTHMS IN BRAIN CELLS THROUGH CELL-INTRINSIC DYNAMICS
Göver T.^1,2, Hanus P.^1,3, Środa-Pomianek K.², Ślęzak M.^1
1 Research Group Biology of Astrocytes, Łukasiewicz Research Network - PORT Polish Center for Technology Development, Wrocław, Poland., ² Department of Biophysics and Neuroscience, Wroclaw Medical University, Wrocław, Poland., ³ Department of Psychiatry, Wroclaw Medical University, Wrocław, Poland.

TRANSCRIPTIONAL SIGNATURES OF HUMAN NEURAL CELLS TO GLUCOCORTICOID STIMULATION
Conțu V.R.¹, Piechota M.², Korostyński M.², Ślęzak M.^1
1 Łukasiewicz Research Network – PORT Polish Center for Technology Development, Wroclaw, Poland, ² Laboratory of Pharmacogenomics, Department of Molecular Neuropharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland

MODULATING MICROGLIAL AUTOPHAGY WITH IBRUTINIB: INSIGHTS FROM IN VITRO PHARMACOLOGY
Das D.¹, Mali A.S.², Greco D.³, Michaličková D.¹, Novotný J.³, Slanař O.^1
1 Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital Prague, Prague, Czech Republic, ² A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ³ Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic

THE OVEREXPRESSION OF PGC1Α SUPPORTS NEURONAL MATURATION IN DORSAL FOREBRAIN ORGANOID MODEL
Kuczyńska Z., Wasilewski K., Leszczyński P., Liput M., Metin E., Bużańska L.
Mossakowski Medical Research Institute, Department of Stem Cell Bioengineering, Pawinskiego 5, Warsaw, Poland

ACTIVATION OF TARCE-AMINE ASSOCIATED RECEPTOR (TAAR1): MOLECULAR CHANGES INDUCED BY TAAR1 AGONISTS
Kokhanovska S.^1,2,3, Skieterska K.¹, Skowrońska K.¹, Moroz A.¹, Mroczkiewicz M.¹, Mach M.¹, Tuz D.¹, Smuga D.¹, Pietruś W.¹, Dubiel K.¹, Matłoka M.¹, Bużańska L.^2
1 Celon Pharma S.A., R&D Centre, 15 Marymoncka St., Kazun Nowy, Poland, ² Mossakowski Medical Research Institute, Polish Academy of Sciences, Department of Stem Cell Bioengineering, 5 Pawińskiego St., Warsaw, Poland, ³ Doctoral School of Translational Medicine, Centre of Postgraduate Medical Education, 99/103 Marymoncka St., Warsaw, Poland

MECHANOSENSITIVE PIEZO ION CHANNELS REGULATE OLIGODENDROCYTE MATURATION AND MYELINATION
Pobiarzyn P., Rutkowska A.
Medical University of Gdańsk, Department of Anatomy, Division of Anatomy and Neurobiology, Dębinki 1 80-211, Gdańsk, Poland

DIVERGENT REGULATION OF MTOR AND RAPTOR IN MATURE HIPPOCAMPAL NEURONS DURING NUTRIENT STRESS AND SYNAPTIC ACTIVATION.
Orzoł K., Macias M., Jaworski J.
International Institute of Molecular and Cell Biology in Warsaw

DIFFERENTIAL BIOENERGETIC REMODELING BY TDP-43 DEPLETION REVEALS AMPK-MEDIATED MOTOR NEURON HYPERMETABOLISM
Gbadamosi I.¹, Motherwell L.¹, Guntan I.¹, Dymkowska D.², Jawaid A.^1
1 Translational Neuropsychiatry Research Group, Life Sciences and Biotechnology Center, Lukasiewicz Research Network–PORT Polish Center for Technology Development, Warsaw, Poland, ² Laboratory of Cellular Metabolism, Nencki Institute of Experimental Biology, Warsaw, Poland

LIPID METABOLISM MODULATES MICROGLIAL PHAGOCYTOSIS OF AMYLOID-BETA
Lepiarz-Raba I.¹, Hidayat T.², Tomaszewska W.², Jawaid A.², Binias S.³, Gielniewski B.³, Miłek J.⁴, Dziembowska M.^4
1 Translational Research in Exposures and Neuropsychiatric Disorders (TREND), Nencki Institute of Experimental Biology PAS, Warsaw, Poland, ² Translational Neuropsychiatry Research Group, Łukasiewicz-PORT, Wrocław, Poland, ³ Laboratory of Sequencing, Nencki Institute of Experimental Biology PAS, Warsaw, Poland, ⁴ Department of Biology, University of Warsaw, Warsaw, Poland

DIET-DRIVEN NEUROINFLAMMATION AND BRAIN INSULIN RESISTANCE: UNVEILING THE WESTERN DIET’S ROLE IN ALZHEIMER’S PATHOLOGY.
Domańska J., Mietelska-Porowska A., Więckowska-Gacek A., Wojda U.
Nencki Institute of Experimantal Biology, Polish Academy of Sciences, Laboratory of Preclinical Testing of Higher Standard, 3 Pasteur St. 02-093 Warsaw, Poland

EVALUATION OF NEUROPROTECTIVE POTENTIAL OF CLASSICAL AND NOVEL ANTI-INFLAMMATORY COMPOUNDS FOR PARKINSON’S DISEASE – IN VITRO STUDY IN HUMAN NEUROBLASTOMA SH-SY5Y CELLS
Jantas D.¹, Mąsior A.¹, Chmielarz P.¹, Bugno R.², Kreiner G.^1
1 Maj Institute of Pharmacology Polish Academy of Sciences, Department of Brain Biochemistry, Smętna 12 Str, 31-343 Kraków, Poland, ² Maj Institute of Pharmacology Polish Academy of Sciences, Department of Medicinal Chemistry, Smętna 12 Str, 31-343 Kraków, Poland

EXPLORING THE ROLE OF THE ANTERIOR CINGULATE CORTEX IN ADHD- AND SCHIZOPHRENIA-RELATED DYSFUNCTIONS USING BEHAVIOURAL ANALYSIS, CHEMOGENETICS, MACHINE-LEARNING, OPTO- AND ELECTROPHYSIOLOGY
der Veen B.v., Jendryka M.M., Kapanaiah S.K., Kätzel D.
Institute of Applied Physiology, Ulm University

INTERDEPENDENCY BETWEEN OXYTOCIN AND DOPAMINE IN TRUST-BASED LEARNING IN MICE
Budniok S.^1,2,3, Callaerts-Vegh Z.^1,3, Bakermans-Kranenburg M.^4,5, Bosmans G.^2,3, D'Hooge R.^1,3
1 KU Leuven, Laboratory of Biological Psychology, Tiensestraat 102, Leuven, Belgium, ² KU Leuven, Learn2Trust Research Group, Tiensestraat 102, Leuven, Belgium, ³ KU Leuven, Leuven Brain Institute, Herestraat 49, Leuven, Belgium, ⁴ ISPA - University Institute of Psychological, Social and Life Sciences, William James Center for Research, Rua Jardim do Tabaco 34, Lisbon, Portugal, ⁵ Universidad San Sebastián, Facultad de Psicología y Humanidades, Bellavista 7, Santiago, Chile

THE SWITCHBOARD TEST: A FLEXIBLE, LOW-COST PLATFORM FOR STUDYING SPATIAL MEMORY IN RATS DURING SEQUENTIAL INSTRUMENTAL TASKS
Sahu R.¹, Żakowski W.², Maćkiewicz K.^1,2, Polniak O.², Wiśniewski D.³, Kotus J.³, Niediek J.⁴, Aggleton J.P.⁵, O’Mara S.M.⁶, Jankowski M.M.^1
1 BioTechMed Center, Multimedia Systems Department, Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Gdansk, Poland, ² Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland, ³ Multimedia Systems Department, Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Gdansk, Poland, ⁴ Machine Learning Group, Technische Universität Berlin, Berlin, Germany, ⁵ School of Psychology, Cardiff University, Cardiff CF10 3AT, United Kingdom, ⁶ Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland

MODES OF SOCIAL COOPERATION IN RATS PERFORMING A SEQUENTIAL SPATIAL MEMORY TASK
Sahu R.¹, Żakowski W.², Maćkiewicz K.^1,2, Polniak O.², Niediek J.³, Czajkowski R.⁴, Knapska E.⁵, Aggleton J.P.⁶, O’Mara S.M.⁷, Jankowski M.M.^1
1 BioTechMed Center, Multimedia Systems Department, Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Gdansk, Poland, ² Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland, ³ Machine Learning Group, Technische Universität Berlin, Berlin, Germany, ⁴ Laboratory of Spatial Memory, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland, ⁵ Laboratory of Neurobiology of Emotions, Nencki-EMBL Partnership for Neural Plasticity and Brain Disorders–BRAINCITY, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland., ⁶ School of Psychology, Cardiff University, Cardiff CF10 3AT, United Kingdom, ⁷ Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland

LOOKING FOR DISTINCT POPULATIONS OF CELLS CODING SOCIAL STIMULI IN CENTRAL AMYGDALA
Badyra B.¹, Meyza K.¹, Nanda S.¹, Santoro M.^1,2, Menon G.^1,3, Knapska E.^1
1 Laboratory of Emotions Neurobiology, Nencki Institute of Experimental Biology PAS, Warsaw, ² Departament of Physiology and Pharmacology “V.Erspamer” Sapienza, University of Rome, Italy, ³ National Institute of Science Education and Research, Bhubaneswar, India

MANIPULATION OF PREFRONTAL SOMATOSTATIN INTERNEURON ACTIVITY AFFECTS EMOTIONAL CONTAGION
Meyza K.¹, Nikolaev T.¹, Goszczyńska E.^2,3, Roszkowska N.¹, Sadowska J.¹, Górkiewicz T.¹, Knapska E.^1
1 Nencki Institute of Experimental Biology, Warsaw, Poland, ² International Max Planck Research School for Neurosciences, Gottingen, Germany, ³ Georg August Unoversity of Gottingen, Germany

THE DYNORPHIN– Κ OPIOID RECEPTOR SYSTEM SHAPES SOCIAL RECOGNITION MEMORY
Rzeszut A.¹, Misiołek K.¹, Netczuk J.¹, Szumiec Ł.¹, Gołębiowska K.², Parkita J.R.^1
1 Maj Institute of Pharmacology Polish Academy of Sciences, Department of Molecular Neuropharmacology, 12 Smętna St., Krakow, Poland, ² Maj Institute of Pharmacology of the Polish Academy of Sciences, Department of Pharmacology, Krakow, Poland

TCF7L2 DEFICIENCY IN THE THALAMUS LEADS TO ALTERATIONS IN THE SOCIAL BEHAVIOUR PROFILE
Baggio S.¹, Nagalski A.¹, Koziński K.¹, Szewczyk Ł.M.¹, Lipiec M.A.², Meyza K.², Kiryk A.³, Goncarzewicz A.², Szczepańska L.², Knapska E.², Wojda U.³, Wiśniewska M.B.^1
1 Centre of New Technologies, University of Warsaw, Warsaw, Poland, ² BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Warsaw, Poland, ³ Center of Neurobiology, Nencki Institute of Experimental Biology, Warsaw, Poland

SAFEGUARDING OBJECT-DIRECTED BEHAVIOR: THE ROLE OF ENTORHINAL-AMYGDALA CIRCUITS
Piszczek Ł.¹, Böhm V.², Bednarz A.¹, Pliota P.², Kraitsy K.³, Haubensak W.^1,2
1 Medical University of Vienna, Center for Brain Research, Vienna, Austria, ² The Research Institute of Molecular Pathology (IMP), Vienna, Austria, ³ BioCenter Core Facilities, Preclinical Phenotyping, Vienna, Austria

SWEET CONSEQUENCES: UNRAVELING THE IMPACT OF DIETARY SUGAR ON WEIGHT GAIN AND COGNITIVE FUNCTION IN MICE
Chwastek J.¹, Bartochowski P.², Zglinicki B.^1,2, Pietrzyk O.¹, Olech-Kochańczyk G.², Bartelik A.³, Kochańczyk M.⁴, Konopka A.¹, Kiryk A.², Konopka W.^1,2
1 Łukasiewicz Research Network - PORT Polish Center for Technology Development, Wrocław, Poland, ² Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland, ³ International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic, ⁴ Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland

EFFECT OF IRON ADMINISTERED IN THE NEONATAL PERIOD ON THE BEHAVIORAL AND BIOCHEMICAL PARAMETERS IN ADULT RATS
Rogóż Z.^1,2, Kamińska K.¹, Wąsik A.^1
1 Maj Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland, ² University of Applied Sciences, Institute of Health, Faculty of Cosmetology, Nowy Targ, Poland

IMMOBILITY RELATED THETA RHYTHM IN THE POSTERIOR HYPOTHALAMIC AREA IN FREELY MOVING RATS
Pszczółkowska K.^1,,2, Caban B.¹, Bocian R.¹, Kowalczyk T.^1
1 University of Lodz, Faculty of Biology and Environmental Protection, Department of Neurobiology, 141/143 Pomorska Street, 90-236 Lodz, Poland, ² University of Lodz Doctoral School of Exact and Natural Sciences, 21/23 Jana Matejki Street, 90-237 Lodz, Poland

NEUROPROTECTIVE ROLE OF VOLUNTARY PHYSICAL ACTIVITY IN MICE C57BL/6 EXPOSED TO METHAMPHETAMINE
Dębiec M.^1,3, Nowacka-Chmielewska M.¹, Smolarz M.^1,4, Bogus K.², Barski J.³, Małecki A.¹, Toborek M.^1,5
1 Laboratory of Molecular Biology, Institute of Physiotherapy and Health Sciences, Academy of Physical Education, Katowice, Poland, ² Department of Histology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland, ³ Department of Physiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland, ⁴ Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland, ⁵ University of Miami Miller School of Medicine, Department of Biochemistry and Molecular Biology, Miami, FL, USA

THE ROLE OF LIPID METABOLISM AND CIRCULATING MIRNAS IN THE INTERGENERATIONAL TRANSMISSION OF THE EFFECTS OF PARENTAL ADVERSE CHILDHOOD EXPERIENCES
Gomółka M.¹, Tomaszewska W.¹, Binias S.², Nadalinska R.¹, Jawaid A.^1
1 Translational Neuropsychiatry Research Group (TREND Lab) Life Sciences & Biotechnology Center Łukasiewicz Research Network PORT – Polish Centre of Technology Development, Wrocław, Poland, ² Laboratory of Sequencing, Nencki Institute of Experimental Biology PAS, Warsaw, Poland

THE ROLE OF FPR2 IN THE AGE-RELATED CHANGES IN THYMUS-BRAIN AXIS
Grygier B., Łukowicz K., Frydrych J., Trojan E., Głombik K., Basta-Kaim A.
Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology Polish Academy of Sciences

NEUROPROTECTIVE POTENTIAL OF BIFIDOBACTERIUM ANIMALIS CCDM 366 AND ITS BEVS: IMPACT ON THE BLOOD-BRAIN BARRIER FUNCTION.
Zabłocka A.¹, Kozakiewicz D.¹, Małek N.², Jakubczyk D.¹, Macała J.¹, Górska S.^1
1 Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Laboratory of Microbiome Immunobiology, 53-114, Wroclaw, Poland, ² Wroclaw University of Science and Technology, Department of Chemical Biology and Bioimaging, Faculty of Chemistry, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland

AGING IN AN ARTIFICIAL WORLD: EXPLORING THE RETINAL AND BEHAVIORAL CONSEQUENCES OF LIGHT POLLUTION IN AGING DROSOPHILA MELANOGASTER
Skoczek K., Damulewicz M.
Jagiellonian University, Institute of Zoology and Biomedical Research, Department of Cell Biology and Imaging, 9 Gronostajowa St., Kraków, Poland

EXPLORING RETINAL AGEING IN A LIGHT-POLLUTED ENVIRONMENT ON DROSOPHILA MELANOGASTER AS A MODEL
Mitka M.^1,2, Damulewicz M.^1
1 Jagiellonian University, Institute of Zoology and Biomedical Research, Department of Cell Biology and Imaging, 9 Gronostajowa St., Cracow, Poland, ² Jagiellonian University, Doctoral School of Exact and Natural Sciences, 11 Łojasiewicza St., Cracow, Poland

THE ROLE OF STIM2 IN RETINAL NEURODEGENERATION
Baranykova S.¹, Wasilewska I.², Macias M.³, Szybińska A.³, Węgierski T.³, Kuźnicki J.¹, Majewski Ł.^1
1 Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, Poland, ² Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland, ³ Microscopy and Cytometry Facility, International Institute of Molecular and Cell Biology, Warsaw, Poland

PREVENTING COGNITIVE DECLINE THROUGH COGNITIVE ENGAGEMENT: WHAT CAN WE LEARN FROM ADULT LEARNERS
Miller D.A.
UNiversity of Wolverhampton, Department of Psychology, Faculty of Health and Life Science, Wulfruna Street Wolverhampton WV1 1LY

AMOTL2 IN THE BRAIN: FROM DEVELOPMENT TO POSTNATAL
Joshi I.^1,2, Kischel A.¹, Kaczor P.¹, Rojek K.O.³, Prószyński T.J.^1
1 Laboratory of Synaptogenesis, Łukasiewicz Research Network – PORT Polish Center for Technology Development, Stabłowicka 147, 54-066 Wrocław, Poland, ² Ludwik Hirszfeld Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wrocław, Poland, ³ Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

COMPARATIVE HISTOLOGICAL ANALYSIS OF CORTICAL DEVELOPMENT IN BTBR AND C57BL/6 MOUSE MODELS AT MID-GESTATION STAGES: IMPLICATIONS FOR NEURODEVELOPMENTAL DISORDERS
Czyrska J., Sampino S., Viscomi M.P., Ziętek M., Cybulska M.
Institute of Genetics and Animal Biotechnology of Polish Academy of Sciences

EARLY-LIFE NUTRITIONAL STRESS MODULATES LEPTIN-INDUCED AXONAL GROWTH IN A SEX-DEPENDENT MANNER
Gutkowska-Kawka D., Guzewska M.M., Kaczmarek M.M.
Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland

REISSNER FIBER FORMATION REQUIRES MULTIPLE DEVELOPMENTAL INPUTS INCLUDING POTASSIUM CHANNELS AND GRAVITY
Amini R.R., Jain R.P., Korzh V.
International Institute of Molecular and Cell Biology in Warsaw, 4 Ks. Trojdena St., Poland

IDENTIFICATION OF THE MECHANISMS AND BIOMARKERS OF MCOPS12 TO PROPOSE TREATMENT STRATEGIES
Krystyniak A.^1,2,3, Krężel W.^1,2, Dobryszycki P.^3
1 IGBMC, Developmental Biology and Stem Cells, 1 Rue Laurent Fries, BP 10142, 67400 Illkirch, France, ² University of Strasbourg, Doctoral School of Life Sciences, 46 boulevard de la Victoire, 67000, Strasbourg, France, ³ Wrocław University of Science and Technology, Departament of Biochemistry, Molecular Biology and Biotechnology, Wybrzeże Stanisława Wyspiańskiego 27, 50-370 Wrocław, Polska

CONTRIBUTION OF RXRG-DEPENDENT OLIGODENDROCYTE TO AGING- AND DISEASE-ASSOCIATED OLIGODENDROGENESIS
Brassart Q., Krężel W., Jung M., Baldassarro A.
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR7104, Inserm U1258, 1 rue Laurent Fries 67404 Illkirch Graffenstaden France

A NOVEL CROSS-SPECIES P-TAU217 IMMUNOASSAY FOR INVESTIGATING ANIMAL MODELS OF ALZHEIMER'S DISEASE
González-Mayoral A.¹, Gonzalez-Ortiz F.², Potier M.¹, Blennow K.^1,2,3, Villain N.^1,4
1 Sorbonne Université, INSERM U1127, CNRS 7225, Paris Brain Institute - PBI, Paris, France, ² University of Gothenburg, Department of Psychiatry And Neurochemistry, Institute of Neuroscience And Physiology, The Sahlgrenska Academy At The University Of Gothenburg, Mölndal, Sweden, ³ Sahlgrenska University Hospital, Clinical Neurochemistry Laboratory, Mölndal, Sweden, ⁴ Département de Neurologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP Sorbonne Université, Institute of Memory and Alzheimer’s Disease, Paris, France

MITOCHONDRIAL BIOGENESIS ON PAUSE: MTDNA DOWNREGULATION DESPITE PGC1A UPREGULATION IN EARLY HUMAN EBS
Metin E., Kuczyńska Z., Liput M., Leszczyński P., Bużańska L.
Mossakowski Medical Research Institute, Polish Academy of Sciences, Department of Stem Cell Bioengineering, Adolfa Pawińskiego 5, 02-106, Warsaw, Poland

MODELING NEURONAL AGING IN HIPSC-DERIVED DOPAMINERGIC NEURONS: D-GALACTOSE-INDUCED EPIGENETIC DEREGULATION, MITOCHONDRIAL DYSFUNCTION, AND SENESCENCE-ASSOCIATED PHENOTYPES
Leszczyński P., Duchnowska A., Kuczyńska Z., Liput M., Metin E., Bużańska L.
Department of Stem Cell Bioengineering, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland

BRINGING MARMOSET TO EBRAINS
Majka P.^1,2, Bai S.², Datta A.¹, Łabuszewska K.¹, Syc M.¹, Walkiewicz T.¹, Rosa M.^2
1 Laboratory of Neuroinformatics, Nencki Institute of Experimental Biology of the Polish Academy of Sciences, 02-093 Warsaw, Poland, ² Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, VIC 3800, Australia

MAPPING CELLULAR DIVERSITY AND SPATIAL ARCHITECTURE USING CUTTING-EDGE TRANSCRIPTOMIC TECHNOLOGIES
Valihrach L.^1,2, Masova A.¹, Kulinich V.¹, Abaffy P.^1,2
1 Institute of Biotechnology of the Czech Academy of Sciences, GeneCore Facility, BIOCEV, Prumyslova 595, Vestec, Czech Republic., ² Institute of Biotechnology of the Czech Academy of Sciences, GliaOmics Lab, BIOCEV, Prumyslova 595, Vestec, Czech Republic.

TOPOGRAPHIC MAPPING OF VISUAL INPUT TO DOPAMINERGIC MIDBRAIN STRUCTURES IN THE RAT
Mierniczek O., Błasiak T.
Department of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland

A BIOORTHOGONAL PUTRESCINE PROBE TO TRACK POLYAMINE UPTAKE AND FLUX UNDER NEUROTOXIC STRESS
Owczarek A.¹, Duchnowska A.^1,2, Skweres A.^1,2, Nalepa M.¹, Florkowska A.³, Suchożebski F.¹, Mąka A.¹, Węgrzynowicz M.^1
1 Mossakowski Medical Research Institute, Polish Academy of Sciences, Laboratory of Molecular Basis of Neurodegeneration, Pawińskiego 5, 02-106, Warsaw, Poland, ² Centre of Postgraduate Medical Education, Doctoral School of Translational Medicine, Marymoncka 99/103, 01-813 Warsaw, Poland, ³ International Institute of Molecular Mechanisms and Machines, Polish Academy of Sciences, Laboratory of Stem Cell RNA Metabolism, Flisa 6, 02-247 Warsaw, Poland

A RAPID IMMUNOFLUORESCENCE METHOD COMPATIBLE WITH FUNCTIONAL ASSAYS IN ACUTE AND ORGANOTYPIC SLICES
Duchnowska A.^1,2, Owczarek A.¹, Skweres A.^1,2, Podgajna M.¹, Łukasiewicz J.¹, Węgrzynowicz M.^1
1 Laboratory of Molecular Basis of Neurodegeneration, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawińskiego St., 02-106, Warsaw, Poland, ² Doctoral School of Translational Medicine, Centre of Postgraduate Medical Education, 99/103 Marymoncka St., 01-813 Warsaw, Poland

OVERCOMING LIMITATIONS OF OPTOGENETICS: CAN WE AMPLIFY THE SIGNAL?
Gumkowska M.^1,2, Płaczkiewicz J.^1,2, Foik A.T.^1,2
1 International Centre for Translational Eye Research, Institute of Physical Chemistry PAS, Skierniewicka 10a, 01-230 Warsaw, Poland, ² Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

A LOW-COMPUTATIONAL PIPELINE FOR POST-DEEPLABCUT ANALYSIS OF OPEN FIELD TEST DATA USING CENTROID-BASED SPATIAL METRICS
Kramarska E.¹, Babeshko O.¹, Krzywińska E.¹, Kucharczyk M.^1,2
1 Cancer Neurophysiology Group, Łukasiewicz Research Network – PORT Polish Center for Technology Development, Wrocław, Poland, ² Wolfson Sensory, Pain and Regeneration Centre, King’s College London, London, UK

FUNCTIONAL INTRODUCTION OF RABIES VIRUS TO HEALTHY AND DEGENERATED RETINA
Galińska A.^1,2, Płaczkiewicz J.^1,2, Saran K.^1,2, Gumkowska M.^1,2, Foik A.T.^1,2
1 International Centre for Translational Eye Research, Institute of Physical Chemistry PAS, Skierniewicka 10a, 01-230 Warsaw, Poland, ² Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

SEARCHING FOR THE PARAMETERS OF NEURON-SPECIFIC EXPRESSION OF AAV VECTORS IN THE MOUSE HYPOTHALAMUS
Pietrzyk O., Konopka W.
Lukasiewicz Research Network – PORT Polish Center for Technology Development, Neuroplasticity and Metabolism Research Group, Stablowicka 147 St., Wroclaw, Poland

INVESTIGATING THE ROLE OF A VCP/P97 COFACTOR SVIP IN MODULATING HUNTINGTON’S DISEASE PHENOTYPES
Cierluk K., Shrivastava R., Krzyżosiak A.
Łukasiewicz Research Network - PORT Polish Center for Technology Development, Mechanisms of Neurodegeneration Group

ASSESSMENT OF MITOPHAGY IN HUMAN SUBPALLIAL ORGANOIDS ENRICHED WITH GABAERGIC NEURONS IN DRAVET SYNDROME
Tyszko P.^1,2, Zychowicz M.¹, Zayat V.¹, Liput M.¹, Kuczyńska Z.¹, Metin E.¹, Bużańska L.^1
1 Mossakowski Medical Research Institute, Department of Stem Cell Bioengineering, Pawinskiego 5 str, Warsaw, Poland, ² Warsaw University of Life Science, Faculty of Biology and Biotechnology, Nowoursynowska 166 str, Warsaw, Poland

INTEGRATING COMPUTATIONAL AND EXPERIMENTAL APPROACHES TO REVEAL TAURINE’S NEUROPROTECTIVE ROLE IN RETINAL ISCHEMIA
Agrafiotis G.¹, Gkinis D.¹, Avramouli M.², Savvas I.², Stamatiou R.³, Papoutsopoulou S.⁴, Vasilaki A.^1
1 University of Thessaly, Faculty of Medicine, Laboratory of Pharmacology, BIOPOLIS, 41500 Larissa, Greece, ² University of Thessaly, Department of Digital Systems, GAIOPOLIS, 41500 Larissa, Greece, ³ University of Thessaly, Faculty of Medicine, Laboratory of Physiology, BIOPOLIS, 41500 Larissa, Greece, ⁴ University of Thessaly, Department of Biochemistry & Biotechnology, BIOPOLIS, 41500 Larissa, Greece

ACTIVITY-DEPENDENT ANTIOXIDANT GENE THERAPY FOR EPILEPSY
Singh P.K., Shekh-Ahmad T.
The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel

MUSCLEBLIND-LIKE RNA BINDING PROTEIN TRAFFICKING DYNAMICS ARE REGULATED BY MOLECULAR INTERACTIONS WITH EARLY AND RECYCLING ENDOSOMES
Janusz-Kamińska A.¹, Shen A.¹, Fernandez P.², Knudson L.¹, Zhou E.¹, Hildebrandt R.², Wang E.T.², Bassell G.J.^1
1 Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA, ² Center for Neurogenetics, Dept. of Molecular Genetics, University of Florida, Gainesville, FL, USA

MULTICENTRIC STUDY OF LONGITUDINAL CHANGES IN NEUROMELANIN MRI SIGNAL AS A PROGRESSION MARKER IN PARKINSON'S DISEASE
Baron A.^1,2,3,4, Gaurav R.^1,2,3,4, Lejeune F.^1,2,6, Valabrègue R.^1,2,3, Arnulf I.^1,2,5, Corvol J.^1,2,5, Vidailhet M.^1,2,4, Lehéricy S.^1,2,3,4
1 Sorbonne University, 21 rue de l'École de Médecine, Paris, France, ² Paris Brain Institute /CNRS UMR 7225/INSERM U 1127, Paris, France, ³ Paris Brain Institute, Neuroimaging Research Center – CENIR, Hôpital Pitié-Salpêtrière 47 bd de l'Hôpital, Paris, France, ⁴ Paris Brain Institute, Movement Investigations and Therapeutics (MOV'IT) team, Hôpital Pitié-Salpêtrière 47 bd de l'Hôpital, Paris, France, ⁵ Paris Brain Institute, Neuroscience Clinical Investigation Center (CIC), Hôpital Pitié-Salpêtrière 47 bd de l'Hôpital, Paris, France, ⁶ Paris Brain Institute, Data analyse core (DAC), Hôpital Pitié-Salpêtrière 47 bd de l'Hôpital,Paris, France.

GUT–BRAIN AXIS MODULATION OF SYMPTOMS IN EARLY PARKINSON’S DISEASE: EVIDENCE FROM A PILOT STUDY
Lorek K.¹, Markowska K.², Bereza A.², Budrewicz S.², Koziorowska-Gawron E.², Stankowska K.¹, Ściepuro T.¹, Marusiak J.^1
1 Wroclaw University of Health and Sport Sciences, Faculty of Physiotherapy, Department of Physiotherapy in Movement System Dysfunctions and Kinesiology, ² Wroclaw Medical University, Department of Neurology

INVESTIGATING THE CONTRIBUTIONS OF IMAGE QUALITY TRANSFER IN THE DIAGNOSIS AND UNDERSTANDING OF PARKINSON'S DISEASE
Langlois M.^1,2, Valabrègue R.³, Didier M.³, Gaurav R.¹, Ouarab S.³, Lejeune F.⁴, Kozlowski E.^1,2, Lehéricy S.^1,2,3
1 Paris Brain Institute (ICM), MovIt, Hôpital Pitié, 47 Bd de l'Hôpital, Paris, France, ² Sorbonne Université, Ecole Cerveau Cognition Comportement (ED3C), Paris, France, ³ Paris Brain Institute (ICM), CENIR, Hôpital Pitié, 47 Bd de l'Hôpital, Paris, France, ⁴ Paris Brain Institute (ICM), DAC, Hôpital Pitié, 47 Bd de l'Hôpital, Paris, France

IRON-CALCIUM CROSSTALK AND FERROPTOSIS IN LRRK2-LINKED PARKINSON’S DISEASE. NEUROPROTECTIVE ROLE OF MCU INHIBITION
Moskal A., Skarżyńska W., Kuźnicki J.
International Institute of Molecular and Cell Biology, Laboratory of Neurodegeneration, Warsaw, Poland

ESTIMATION OF THE THERAPEUTIC POTENTIAL OF THE ANTI-INFLAMMATORY DRUGS IN THE TREATMENT OF PARKINSON'S DISEASE
Zelek-Molik A.¹, Alwani A.¹, Roman A.¹, Bielawski A.¹, Lenda T.², Chmielarz P.¹, Konieczny J.¹, Kreiner G.^1
1 Maj Institute of Pharmacology Polish Academy of Sciences, Department of Brain Biochemistry, Smętna 12 St, Kraków, Poland, ² Maj Institute of Pharmacology Polish Academy of Sciences, Cephares, Smętna 12 St, Kraków, Poland

ENDOLYSOSOMAL DISRUPTION MODULATES ALPHA-SYNUCLEIN AGGREGATION IN A CELLULAR MODEL OF PARKINSON'S DISEASE.
Wilk Z., Barut J., Chmielarz P.
Maj Institute of Pharmacology, Polish Academy of Sciences, Departament of Brain Biochemistry, Krakow, Poland

NANOMATERIAL-BASED STRATEGIES AGAINST PARKINSON’S-RELATED Α-SYNUCLEIN MISFOLDING AND AGGREGATION
Alwani A.¹, Kowalska O.², Oćwieja M.², Chmielarz P.^1
1 Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Brain Biochemistry, Kraków, Poland, ² Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Department of Colloid and Interface Physicochemistry, Kraków, Poland

INHIBITION OF ALPHA-SYNUCLEIN AGGREGATION AND ER STRESS RESCUES NEURODEGENERATION IN A 3D IN VITRO MODEL OF PARKINSON’S DISEASE
Siwecka N.^1,2, Golberg M.^3,4, Galita G.¹, Rozpędek-Kamińska W.¹, Majsterek I.^1
1 Medical University of Lodz, Department of Clinical Chemistry and Biochemistry, 5 Mazowiecka St., 92-215 Lodz, Poland, ² Medical University of Lodz, Clinical Department of Neurology with Stroke Treatment Unit, University Clinical Hospital No. 1, 22 Kopcinskiego St., 90-153 Lodz, Poland, ³ Medical University of Lodz, Department of Histology and Embryology, 7/9 Zeligowskiego St., 90-752 Lodz, Poland, ⁴ Medical University of Warsaw, Department of Child Psychiatry, Children's Clinical Hospital, 63A Zwirki i Wigury St., 02-091 Warsaw, Poland

A NOVEL ANTI-INFLAMMATORY COMPOUND REDUCE ASTROCYTIC ACTIVATION IN FIBRILLAR MODEL OF PARKINSON'S DISEASE.
Maziarz K.¹, Barut J.¹, Degutis M.¹, Chmielarz P.¹, Bugno R.², Kreiner G.^1
1 Maj Institute of Pharmacology Polish Academy of Sciences, Department of Brain Biochemistry, Smętna 12 Str, 31-343 Kraków, Poland, ² Maj Institute of Pharmacology Polish Academy of Sciences, Department of Medicinal Chemistry, Smętna 12 Str, 31-343 Kraków, Poland

INDUCING NEURODEGENERATION IN ZEBRAFISH TO PROBE FERROPTOTIC PATHWAYS IN PARKINSON'S DISEASE
Dileep M., Sotoudeh N., Baranykova S., Kuźnicki J.
Laboratory of Neurodegeneration, International Institute of Molecular and Cellular Biology, Warsaw, Poland.

THE INFLUENCE OF LIGHT POLLUTION ON SURVIVAL OF PD MODEL DROSOPHILA MELANOGASTER.
Kowalska M., Damulewicz M.
Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, 30-387, Kraków, Poland

THE DOPAMINE IN GLUTAMATERGIC NEURONS AFFECTS SURVIVAL AND MOTOR ABILITIES OF DOROSPHILA MELANOGASTER.
Wawak E., Damulewicz M.
Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Department of Cell Biology and Imaging, Gronostajowa 9, 30-387, Kraków, Poland

THE EFFECT OF PARACETAMOL ON THE PROGRESSION OF PARKINSON'S DISEASE IN THE DROSOPHILA MELANOGASTER MODEL
Szypulski K.^1,2, Damulewicz M.^1
1 Jagiellonian University, Department of Cell Biology and Imaging, Gronostajowa 9, Cracow, Poland, ² Jagiellonian University, Doctoral School of Exact and Natural Sciences, Łojasiewicza 11, Cracow, Poland

ANTI-INFLAMMATORY EFFECT OF EGF-FGF EXOSOMES IN PTZ INDUCED SEIZURE MICE
Wang Y., Liu X.
Zhongshan Hospital,Institute of Brain Science, Fudan University

ZT-1A INHIBITION OF SEIZURE ACTIVITIES BY DUAL MODULATION OF BOTH NKCC1 AND KCC2 EXPRESSION IN EPILEPTIC MICE
Wang B.H.¹, Cai J.², Liu X.^1
1 Department of Neurosurgery and Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China, ² Institutes of Brain Science, Fudan University, Shanghai, China

MUTATIONS AFFECTING KV2.1 SUBUNITS DISRUPT INHIBITORY NEUROTRANSMISSION
Jain R.P., Amini R.R., Korzh V.
International Institute of Molecular and Cell Biology, Laboratory of Neurodegeneration, Księcia Trojdena 4, Warsaw, Poland.

ROLE OF CERT1 IN CONTROL OF MICROGLIA BIOLOGY IN MICE – RELEVANCE FOR COGNITIVE FUNCTIONS
Parekh Y.¹, Krezel P.¹, Martinez P.M.², Krężel W.^1
1 Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM, CNRS, Université de Strasbourg, 67404 Illkirch, France, ² Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht 6200MD, the Netherlands

NEUROPHYSIOLOGICAL MARKERS OF BRAIN INJURY IN ACUTE DISORDERS OF CONSCIOUSNESS
Frycz S.^1,2, Binder M.¹, Krycińska R.^2,3, Terlecki M.^3
1 C-lab, Institute of Psychology, Jagiellonian University, Krakow, Poland, ² Doctoral School of Social Sciences, Jagiellonian University, Krakow, Poland, ³ Department of Interdisciplinary Intensive Care, Jagiellonian University Collegium Medicum and University Hospital

THE PROGRESSION OF ALS IN THE SKELETAL MUSCLES AFTER SWIM TRAINING IN FEMALE AND MALE MICE
Saadat A.¹, Krawczyk I.¹, Cedro B.², Piekarska A.², Flis D.², Ziółkowski W.³, Pyza E.^1
1 Department of Cell Biology and Imaging, Jagiellonian University, Kraków, Poland, ² Department of Pharmaceutical Pathophysiology, Medical University of Gdańsk, Poland, ³ Department of Rehabilitation Medicine, Medical University of Gdańsk, Poland

DOES MTOR-INDUCED BRG1 DEGRADATION INFLUENCE TSC-RELATED SYNAPTIC DYSFUNCTION?
Kumari S.¹, Bogusz K.¹, Hojka-Osińska A.¹, Węgierski T.¹, Liszewska E.¹, Jaworski J.^1
1 International Institute of Molecular and Cell Biology in Warsaw, 4 Ks. Trojdena Street, Warsaw, Poland, ² International Institute of Molecular and Cell Biology in Warsaw,4 Ks. Trojdena Street, Warsaw, Poland, ³ International Institute of Molecular and Cell Biology in Warsaw, 4 Ks. Trojdena Street, Warsaw, Poland, ⁴ International Institute of Molecular and Cell Biology in Warsaw, 4 Ks. Trojdena Street, Warsaw, Poland, ⁵ International Institute of Molecular and Cell Biology in Warsaw, 4 Ks. Trojdena Street, Warsaw, Poland, ⁶ International Institute of Molecular and Cell Biology in Warsaw,4 Ks. Trojdena Street, Warsaw, Poland

INVESTIGATION OF THE ANALGESIC POTENCY, METABOLIC IMPACT, AND EFFECTS ON LOCOMOTOR ACTIVITY OF THE NOVEL HISTAMINE H₃ RECEPTOR ANTAGONIST, LINS01022, IN A MURINE MODEL OF NEUROPATHIC PAIN
Królewski M.¹, Maciuszek M.¹, Białoń M.¹, Fiocchi N.A.², Lopes F.B.², S. Fernandes J.P.², Popiołek-Barczyk K.^1
1 Department of Neurochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12 street, 31-343 Cracow, Poland, ² Department of Pharmaceutical Sciences, Federal University of São Paulo, Diadema, Brazil

A NEW MOLECULAR MECHANISM OF NEUROPLASTICITY
Uygar B.¹, Zeng H.¹, Indukuri R.¹, Arroyo Garcia L.E.^2
1 Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Biomedicum, Solnavägen 9, Stockholm, Sweden, ² Karolinska Institutet, Department of Neurobiology, Health Sciences and Society, Division of Neurogeriatrics, BioClinicum, Visionsgatan 4, Stockholm, Sweden

PLASTICITY OF LAYER 1 INTERNEURONS OF THE MOUSE VISUAL CORTEX
Nozownik A.¹, Rabbani F.¹, Nguyen M.¹, Chiantia G.², Zerlaut Y.¹, Bacci A.¹, Lourençop J.^1
1 ICM - Paris Brain Institute, Hôpital de la Salpêtrière, Paris, France, ² University of Turin, Department of Neuroscience, Turin, Italy

NUCLEUS INCERTUS CONNECTIVITY WITH MIDBRAIN CENTRES - IMPLICATIONS FOR STRESS AND REWARD PROCESSING
Roszkowska J.^1,2, Drwięga G.¹, Walczak M.¹, Mierniczek O.^1,2, Gorkowska-Nosal M.^1,2, Pradel K.^1,3, Solecki W.⁴, Błasiak T.^1
1 Jagiellonian University, Department of Neurophysiology and Chronobiology, 9 Gronostajowa St., Cracow, Poland, ² Jagiellonian University, Doctoral School of Exact and Natural Sciences, 11 Łojasiewicza St., Cracow, Poland, ³ University of Cologne, Institute for Systems Physiology, 39 Robert Koch St., Cologne, Germany, ⁴ Jagiellonian University, Department of Neurobiology and Neuropsychology, 4 Łojasiewicza St., Cracow, Poland

RELAXIN-3 AND OXYTOCIN SIGNALING IN THE VENTRAL DENTATE GYRUS: DIVERGENT NEUROMODULATORY ROLES IN STRESS- AND ANXIETY-RELATED CIRCUITS
Trenk A.¹, Przybylska K.^1,2, Gugula A.¹, Stopka G.^1,2, Nogaj A.^1,2, Danielkis F.¹, Ávila C.d.³, Hossain M.A.⁴, Intorcia A.J.⁵, Serrano G.E.⁵, Beach T.G.⁵, Mastroeni D.F.³, Gundlach A.L.⁴, Blasiak A.^5
1 Department of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland, ² Doctoral School of Exact and Natural Sciences, Jagiellonian University, Kraków, Poland, ³ ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute, and School of Life Sciences, Tempe, Arizona, USA, ⁴ The Florey Institute of Neuroscience and Mental Health, and Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia, ⁵ Neuropathology Laboratory, Banner Sun Health Research Institute, Sun City, Arizona, USA

DIVERGENT EFFECTS OF OXYTOCIN AND RELAXIN-3 SIGNALING IN THE VENTRAL DENTATE GYRUS: A NEURONAL BASIS FOR ANXIETY DISORDERS
Stopka G.^1,2, Trenk A.¹, Gugula A.¹, Przybylska K.^1,2, Sambak P.^1,2, Blasiak A.^1
1 Department of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland, ² Doctoral School of Exact and Natural Sciences, Jagiellonian University, Krakow, Poland

SOCIAL BRAIN: THE ROLE OF RELAXIN-3 AND OXYTOCIN SYSTEMS IN REGULATING SOCIOSEXUAL BEHAVIOUR
Czerniak G.¹, Stopka G.^1,2, Przybylska K.^1,2, Drabik S.^1,2, Sambak P.^1,2, Blasiak A.^1
1 Department of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Cracow, Poland, ² Doctoral School of Exact and Natural Sciences, Jagiellonian University, Cracow, Poland

ELECTROPHYSIOLOGICAL AND BEHAVIORAL INSIGHTS INTO THE IPN-VHPC CIRCUIT UNDERLYING SOCIAL STRESS RESPONSES
Drabik S.^1,2, Stopka G.^1,2, Trenk A.¹, Sambak P.^1,2, Czerniak G.¹, Dridi A.², Przybylska K.^1,2, Blasiak A.^1
1 Department of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland, ² Doctoral School of Exact and Natural Sciences, Jagiellonian University, Kraków, Poland

EXPLORING THE NEUROCHEMICAL PROFILE AND FUNCTIONAL CONNECTIVITY OF THE NUCLEUS INCERTUS–VENTRAL HIPPOCAMPUS CIRCUIT: POTENTIAL ROLE IN ANXIETY REGULATION IN RATS AND HUMANS
Przybylska K.^1,2, Trenk A.¹, Gugula A.¹, Nogaj A.^1,2, Czerniak G.¹, Ávila C.d.³, Intorcia A.J.⁴, Serrano G.E.⁴, Beach T.G.⁴, Mastroeni D.F.³, Blasiak A.^1
1 Department of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Jagiellonian University, Cracow, Poland, ² Doctoral School of Exact and Natural Sciences, Jagiellonian University, Cracow, Poland, ³ ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute, and School of Life Sciences, Tempe, Arizona, USA, ⁴ Neuropathology Laboratory, Banner Sun Health Research Institute, Sun City, Arizona, USA

ANGIOMOTIN-LIKE 1 – A NEW PLAYER IN THE BRAIN PHYSIOLOGY
Duda P., Kischel A., Sadlak-Buda J., Prószyński T.J.
Synaptogenesis Research Group, Łukasiewicz Research Network PORT – Polish Centre of Technology Development Stabłowicka 147, 54-066, Wrocław, Poland

DIFFERENCES IN TONIC CURRENT DENSITY DUE TO PLASTICITY INDUCTION IN SST+ CELL SUBTYPES
Droździel P., Lebida K., Mozrzymas J.W.
Wroclaw Medical University, Department of Biophysics and Neuroscience, 50-367 Wroclaw, Poland

NONASSOCIATIVE ILTD AT INTERNEURON–INTERNEURON SYNAPSES IN THE HIPPOCAMPUS
Jabłońska J., Wiera G., Mozrzymas J.W.
Medical University in Wroclaw, Department of Biophysics and Neurobiology, Chałubińskiego 3a, Wrocław, Poland

BIDIRECTIONAL MODULATION OF GABAERGIC SYNAPTIC TRANSMISSION AND PLASTICITY IN VIP INTERNEURONS BY D2-FAMILY DOPAMINE RECEPTORS
Lebida K., Brzdąk P., Droździel P., Mozrzymas J.W.
Wroclaw Medical University, Department of Biophysics and Neurobiology, 50-367 Wroclaw, Poland

ADRENERGIC MODULATION OF INTRINSIC CORTICAL EXCITABILITY IN PREFRONTAL PYRAMIDAL NEURONS
Kurowski P.^1,2, Lach P.^3
1 Medical Univerisity of Warsaw, Centre for Preclinical Research, Laboratory of Physiology and Pathophysiology, 1b Banacha Str., Warsaw, Poland, ² Medical University of Warsaw, Chair and Department of Pharmacotherapy and Pharmaceutical Care, 1 Banacha Str., Warsaw, Poland, ³ Medical University of Warsaw, Faculty of Pharmacy, 1 Banacha Str., Warsaw, Poland

ONCOMETABOLITE D-2HG ALTERS M6A RNA MODIFICATIONS IN IDH MUTANT GLIOMAS TO PROMOTE NEUROGLIOMAL SYNAPTIC SIGNALING
Hayat Y.¹, Castro-Vega L.J.¹, Sanson M.^1,2
1 Sorbonne Université, Inserm UMRS 1127, CNRS UMR 7225, ICM – Institut du Cerveau, F75013 Paris, France; Équipe Labellisée Par La Ligue Nationale Contre Le Cancer., ² Department of Neuro-Oncology, AP-HP, Hôpital Pitié-Salpêtrière, F-75013 Paris, France.

KAINATE-MEDIATED SIGNALLING IN THE OLFACTORY BULB IS INVOLVED IN THE GENERATION OF KETAMINE-ENHANCED HIGH-FREQUENCY OSCILLATIONS (130-180 HZ) IN FREELY MOVING RATS
Prosvirova T.^1,2, Podolecka W.¹, Hunt M.J.^1
1 Nencki Institute of Experimental Biology PAS, Laboratory of Neuroinformatics, 3 Pasteur St., Warsaw, Poland, ² University of Warsaw, Faculty of Psychology, 5/7 Stawki St., Warsaw, Poland

BRAIN TSUNAMIS – MODELING MIGRAINE-LINKED SPREADING DEPOLARIZATION AND THE EFFECT OF VALPROATE
Goszczyńska E.^1,2,3, Carter B.C.^2
1 International Max Planck Research School for Neurosciences, 3 Hermann-Rein St., Göttingen, Germany, ² European Neuroscience Institute Göttingen, Department of Synaptic Physiology and Plasticity, 5 Grisebach St., Göttingen, Germany, ³ University of Göttingen, Wilhelmsplatz 1, Göttingen, Germany

ELECTROPHYSIOLOGICAL PROFILING OF SYNAPTIC DYSFUNCTION IN TOXIN-INDUCED AND GENETIC ZEBRAFISH MODELS OF PARKINSON’S DISEASE
Sotoudeh N., Dileep M., Baranykova S., Kuźnicki J.
Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Warsaw, Poland

LACK OF SORLA UNLOCKS THE PRO-INFLAMMATORY POTENTIAL OF GLIOMA-ASSOCIATED MICROGLIA
Kamińska P.^1,2, Cyranowski S.³, Bakun M.⁴, Sitkiewicz E.⁴, Pilanc-Kudlek P.², Kamińska B.², Malik A.R.^1
1 Cellular Neurobiology Research Group, Faculty of Biology, University of Warsaw, Poland, ² Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology, Warsaw, Poland, ³ Laboratory of Cytometry, Nencki Institute of Experimental Biology, Warsaw, Poland, ⁴ Laboratory of Mass Spectrometry, Institute of Biochemistry and Biophysics, Warsaw, Poland

COMPARATIVE NEUROCHEMICAL AND SAFETY PROFILES OF PSILOCYBIN AND KETAMINE
Wojtas A.¹, Bysiek A.¹, Szpręgiel I.¹, Wawrzczak-Bargiela A.², Maćkowiak M.², Gołembiowska K.^1
1 Maj Institute of Pharmacology, Polish Academy of Sciences; Department of Pharmacology, Unit II; Smętna 12, 31-343 Kraków, Poland, ² Maj Institute of Pharmacology, Polish Academy of Sciences; Department of Pharmacology, Laboratory of Pharmacology and Brain Biostructure; Smętna 12, 31-343 Kraków, Poland

PROMOTING REMYELINATION IN THE CNS BY TARGETING NEUROINFLAMMATION
Yu Y., Caratis F., Konieczna-Wolska K., Fatimah, Pobiarzyn P., Rutkowska A.
Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

PSYCHEDELICS-MEDIATED NEUROIMMUNE SIGNALLING THROUGH 5-HT₂A AND SIGMA-1 RECEPTORS
Yu Y., Rutkowska A.
Medical University of Gdańsk, Division of Anatomy and Neurobiology, M. Skłodowskiej-Curie 3A, 80-210 Gdańsk, Poland

FUNCTIONAL CONSEQUENCES OF INCREASED EBI2 SIGNALING IN GLIAL CELL BIOLOGY AND MYELINATION.
Fatimah, Rutkowska A.
Medical University Gdańsk, Department of Anatomy and Neurobiology, ul. Marii Skłodowskiej-Curie 3A, 80-210, Gdańsk, Poland

THE SILENT NOCICEPTORS AS REGULATORS OF IMMUNE CELLS ACTIVITY
Pietras Ł.¹, Krzywińska E.¹, Kucharczyk M.^1,2
1 Łukasiewicz Research Network - PORT Polish Center for Technology Development, Stabłowicka 147, Wrocław, Poland., ² Wolfson Sensory, Pain and Regeneration Centre, King’s College London, SE1 1UL London, UK

GPR84 MODULATES INFLAMMATORY SIGNALING IN NEUTROPHILS AND MICROGLIA: A DUAL-CELLULAR APPROACH TO CHRONIC PAIN MECHANISMS
Jarco J.¹, Małek N.^2
1 Wroclaw University of Science and Technology, Department of Chemical Biology and Bioimaging, Faculty of Chemistry, Wroclaw, Poland, ² Wroclaw University of Science and Technology, Department of Chemical Biology and Bioimaging, Faculty of Chemistry, Wroclaw, Poland

FROM GENES TO ACTIVITY: INTEGRATED ANALYSIS OF PROTEASOME FUNCTION IN MICROGLIA AND BRAIN REGIONS IN NEUROPATHIC PAIN
Stelmach N.¹, Popiołek-Barczyk K.², Kamińska M.³, Małek N.^1
1 Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, ² Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, ³ Broegelmann Research Laboratory, University of Bergen

IN VIVO INVESTIGATION OF THE SEX-DEPENDENT ANALGESIC EFFECTS OF HISTAMINE H4 RECEPTOR ANTAGONIST IN A MURINE MODEL OF NEUROPATHIC PAIN
Degutis M.¹, Białoń M.¹, Maciuszek M.¹, Więcek M.², Karcz T.², Szczepańska K.³, Pędracka A.¹, Kieć-Kononowicz K.², Starowicz K.¹, Popiołek-Barczyk K.^1
1 Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Neurochemistry, Krakow, 31-343, Poland, ² Jagiellonian University Medical College, Department of Technology and Biotechnology of Drugs, Krakow, 30-688, Poland, ³ Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, Krakow, 31-343, Poland

SEX-DEPENDENT DIFFERENCES IN NEUROPATHIC PAIN: INSIGHTS FROM FUNCTIONAL METABOLIC PHENOTYPING AND IMMUNOLOGICAL ALTERATIONS
Maciuszek M.¹, Białoń M.¹, Barut J.², Kamińska M.³, Starowicz K.¹, Małek N.⁴, Popiołek-Barczyk K.^1
1 Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Neurochemistry, Smetna 12 street, Cracow, Poland, ² Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Brain Biochemistry, Smetna 12 street, Cracow, Poland, ³ University of Bergen, Department of Clinical Science, Faculty of Medicine, Haukelandsveien 28, Bergen, Norway, ⁴ Wroclaw University of Science and Technology, Department of Biological Chemistry and Bioimaging, Faculty of Chemistry, 27 Wybrzeze Stanislawa Wyspianskiego st., Wroclaw, Poland